Aproximación transdiagnóstica en salud mental: implicaciones en la evaluación, diagnóstico y tratamientos psicológicos

Autoría: Jorge Osma, Óscar Peris-Baquero y Verónica Martínez-Borba. Universidad de Zaragoza e Instituto de Investigación Sanitaria de Aragón

Agras, W. S., Walsh, B. T., Fairburn, C. G., Wilson, G. T., & Kraemer, H. C. (2000). A Multicenter Comparison of Cognitive-Behavioral Therapy and Interpersonal Psychotherapy for Bulimia Nervosa. Archives of General Psychiatry, 57(5), 459. https://doi.org/10.1001/archpsyc.57.5.459
American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders, fifth edition, text revision. (DSM-5-TR). American Psychiatric Association.
Barlow, D. H., Farchione, T. J., Fairholme, C. P., Ellard, K. K., Boisseau, C. L., Allen, L. B., & Ehrenreich-May, J. (2011). The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders. Oxford University Press.
Barlow, D. H., Sauer-Zavala, S., Farchione, T. J., Murray, H., Ellard, K., Bullis, J., & Cassiello-Robbins, C. (2018). Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: Therapist guide. (2nd ed.) [Protocolo Unificado para el Tratamiento Transdiagnóstico de los Trastornos Emocionales: Manual del terapeuta. (2.a ed.), traducida por Jorge Osma y Elena Cr. Alianza Editorial.
Brown, T. A., & Barlow, D. H. (2009). A proposal for a dimensional classification system based on the shared features of the DSM-IV anxiety and mood disorders: Implications for assessment and treatment. Psychological Assessment, 21(3), 256–271. https://doi.org/10.1037/a0016608
Brown, T. A., & Barlow, D. H. (2014). Anxiety and related disorders interview schedule for DSM-5 (ADIS-5)-adult and lifetime version: Clinician manual. Oxford University Press.
Bullis, J. R., Boettcher, H., Sauer-Zavala, S., & Barlow, D. H. (2019). What is an emotional disorder? A transdiagnostic mechanistic definition with implications for assessment , treatment , and prevention. Clinical Psychology: Science and Practice, 1–19. https://doi.org/10.1111/cpsp.12278
Carlucci, L., Saggino, A., & Balsamo, M. (2021). On the efficacy of the unified protocol for transdiagnostic treatment of emotional disorders: A systematic review and meta-analysis. Clinical Psychology Review, 87, 101999. https://doi.org/10.1016/j.cpr.2021.101999
Cassiello-Robbins, C., Southward, M. W., Tirpak, J. W., & Sauer-Zavala, S. (2020). A systematic review of Unified Protocol applications with adult populations: Facilitating widespread dissemination via adaptability. Clinical Psychology Review, 101852. https://doi.org/10.1016/j.cpr.2020.101852
Fairburn, C. G. (2008). Cognitive behavior therapy and eating disorders. Guilford Press.
Fairburn, C. G., Cooper, Z., & Shafran, R. (2003). Cognitive behaviour therapy for eating disorders: A “transdiagnostic” theory and treatment. Behaviour Research and Therapy, 41(5), 509–528. https://doi.org/10.1016/S0005-7967(02)00088-8
Ferreres-Galán, V., Navarro-Haro, M. V., Peris-Baquero, Ó., Guillén-Marín, S., de Luna-Hermoso, J., & Osma, J. (2022). Assessment of Acceptability and Initial Effectiveness of a Unified Protocol Prevention Program to Train Emotional Regulation Skills in Female Nursing Professionals during the COVID-19 Pandemic. International Journal of Environmental Research and Public Health, 19(9), 5715. https://doi.org/10.3390/ijerph19095715
Goodman, W. K., Price, L. H., Rasmussen, S. A., Mazure, C., Fleischmann, R. L., Hill, C. L., Heninger, G. R., & Charney, D. S. (1989). The Yale-Brown obsessive compulsive scale: I. Development, use, and reliability. Archives of General Psychiatry, 46(11), 1006–1011.
Grasa, E., Corripio, I., Peris-Baquero, O., Roldán, A., Selma, J., & Osma, J. (2023). Opening Treatment Windows for Treatment-Resistant Schizophrenia: Improving Emotion Regulation Strategies Using the Unified Protocol in a Case Study in Spain. Clinical Case Studies, 15346501231190912. https://doi.org/10.1177/15346501231190912
Harvey, A., Watkins, E., Mansell, W., & Shafran, R. (2004). Cognitive behavioural processes across psychological disorders: A transdiagnostic approach to research and treatment. Oxford University Press.
Institute for Health Metrics and Evaluation (IHME). (2023). Global Health Data Exchange (GHDx). https://www.healthdata.org/spain?language=149
Kennedy, K. A., & Barlow, D. H. (2017). The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: An Introduction. In K. A. Kennedy & D. H. Barlow, Applications of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (pp. 1–16). Oxford University Press. https://doi.org/10.1093/med-psych/9780190255541.003.0001
Martínez-Borba, V., Osma, J., Crespo-Delgado, E., Andreu-Pejo, L., & Monferrer-Serrano, A. (2022). Prevention of Emotional Disorders and Symptoms Under Health Conditions: A Pilot Study using the Unified Protocol in a Fertility Unit. Anales de Psicología, 38(1), 25–35. https://doi.org/10.6018/analesps.462331
Navarro-Haro, M. V., Abanades-Morillo, A., Péris-Baquero, Ó., Martínez-Borba, V., Crespo-Delgado, E., Baquero-Escribano, A., Masferrer-Boix, L., & Osma, J. (2025). Implementation of two transdiagnostic interventions based on emotional regulation for professionals who treat alcohol addiction in the Spanish mental health system: A multicenter mixed methods pilot study protocol. PLOS One, 20(5), e0318512. https://doi.org/10.1371/journal.pone.0318512
Osma, J., Castellano, C., Crespo, E., & García-Palacios, A. (2015). The unified protocol for transdiagnostic treatment of emotional disorders in group format in a spanish public mental health setting. Behavioral Psychology/ Psicologia Conductual, 23(3), 447–466. https://doi.org/10.1177/0145445514553094
Osma, J., Martínez-Loredo, V., Quilez-Orden, A., Peris-Baquero, O., Ferreres-Galán, V., Prado-Abril, J., Torres-Alfosea, M. A., & Rosellini, A. J. (2023). Multidimensional emotional disorders inventory: Reliability and validity in a Spanish clinical sample. Journal of Affective Disorders, 320, 65–73. https://doi.org/10.1016/j.jad.2022.09.140
Osma, J., Martínez-Loredo, V., Quilez-Orden, A., Peris-Baquero, Ó., & Suso-Ribera, C. (2021). Validity Evidence of the Multidimensional Emotional Disorders Inventory among Non-Clinical Spanish University Students. International Journal of Environmental Research and Public Health, 18(16), 8251.
Osma, J, Quilez-Orden, A. B., Ferreres-Galán, V., Meseguer, M. C., & Ariza, S. (2023). Feasibility and clinical usefulness of the Unified Protocol in women survivors of violence. Journal of Child and Family Studies, 32(9), 2598–2613. https://doi.org/10.1007/s10826-022-02226-z
Osma, J., Suso-Ribera, C., García-Palacios, A., Crespo-Delgado, E., Robert-Flor, C., Sánchez-Guerrero, A., Ferreres-Galan, V., Pérez-Ayerra, L., Malea-Fernández, A., & Torres-Alfosea, M. A. (2018). Efficacy of the unified protocol for the treatment of emotional disorders in the Spanish public mental health system using a group format: Study protocol for a multicenter, randomized, non-inferiority controlled trial. Health and Quality of Life Outcomes, 16(1), 46. https://doi.org/10.1186/s12955-018-0866-2
Peláez, T., López-Carrilero, R., Espinosa, V., Balsells, S., Ochoa, S., & Osma, J. (2024). Efficacy of the unified protocol for transdiagnostic treatment of comorbid emotional disorders in patients with ultra high risk for psychosis: Results of a randomized controlled trial. Journal of Affective Disorders, 367, 934–943. https://doi.org/10.1016/j.jad.2024.09.036
Peris‐Baquero, Ó., Fadrique‐Jiménez, A., Prieto‐Rollan, I., Camacho‐Guerrero, L., Martínez‐Lluesma, S., & Osma, J. (2025). Brief Versions of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Spanish Primary Care Service: Results of a Feasibility Pilot Study. Journal of Clinical Psychology, 81(11), 1103–1117. https://doi.org/10.1002/jclp.70016
Peris-Baquero, Ó., Moreno, J. D., & Osma, J. (2022). Long-term cost-effectiveness of group unified protocol in the Spanish public mental health system. Current Psychology. https://doi.org/10.1007/s12144-022-03365-8
Peris-Baquero, O., & Osma, J. (2023). Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Group Format in Spain: Results of a Noninferiority Randomized Controlled Trial at 15 Months after Treatment Onset. Depression and Anxiety, 2023, 1–16. https://doi.org/10.1155/2023/1981377
Quilez-Orden, A., Prado-Abril, J., Ferreres-Galán, V., Torres-Alfosea, M. Á., Santos-Goñi, M. A., Peris-Baquero, Ó., & Osma, J. (2023). Descripción del inventario multidimensional para los trastornos emocionales (MEDI) para la evaluación y diagnóstico dimensional. Acción Psicológica, 19(2). https://doi.org/10.5944/ap.19.2.36992
Rosellini, A. J., & Brown, T. A. (2014). Initial interpretation and evaluation of a profile-based classification system for the anxiety and mood disorders: Incremental validity compared to DSM-IV categories. Psychological Assessment, 26(4), 1212–1224. https://doi.org/10.1037/pas0000023
Rosellini, A. J., & Brown, T. A. (2019). The Multidimensional Emotional Disorder Inventory (MEDI): Assessing transdiagnostic dimensions to validate a profile approach to emotional disorder classification. Psychological Assessment, 31(1), 59–72. https://doi.org/10.1037/pas0000649
Sakiris, N., & Berle, D. (2019). A systematic review and meta-analysis of the Unified Protocol as a transdiagnostic emotion regulation based intervention. Clinical Psychology Review, 72, 101751. https://doi.org/10.1016/j.cpr.2019.101751
Sauer-Zavala, S., Gutner, C. A., Farchione, T. J., Boettcher, H. T., Bullis, J. R., & Barlow, D. H. (2017). Current Definitions of “Transdiagnostic” in Treatment Development: A Search for Consensus. Behavior Therapy, 48(1), 128–138. https://doi.org/10.1016/j.beth.2016.09.004
Schaeuffele, C., Meine, L. E., Schulz, A., Weber, M. C., Moser, A., Paersch, C., Recher, D., Boettcher, J., Renneberg, B., Flückiger, C., & Kleim, B. (2024). A systematic review and meta-analysis of transdiagnostic cognitive behavioural therapies for emotional disorders. Nature Human Behaviour. https://doi.org/10.1038/s41562-023-01787-3
Socías-Soler, J., Martínez-García, L., Peris-Baquero, Ó., & Osma, J. (2024). Results of a brief online group application of the unified protocol for the preventionof emotional disorders in university students: A pilot study with multiple baseline experimental design. Anales de Psicología, 40(2), 179–188. https://doi.org/10.6018/analesps.554261
World Health Organization. (2018). ICD-11 International classification of diseases for mortality and morbidity statistics (11th Revision). Geneva: World Health Organization.